Low-density lipoprotein cholesterol target attainment among statin-naive Chinese atherosclerotic vascular disease patients

Abstract Background Low-density lipoprotein cholesterol (LDL-C) of patients with atherosclerotic vascular disease (ASCVD) is expected to be lowered by ≥50% and <1.4 mmol/L. Despite the use lipid-lowering therapies, most Chinese failed meet treatment target. Purpose We aimed evaluate potential different statin intensities on LDL-C target attainment among statin-naïve ASCVD patients. Methods retrospectively analyzed who were initiated therapy between January July 2020 from 43 public hospitals or clinics in Hong Kong. Patients divided into high-intensity (HI-S, atorvastatin 40–80 mg, rosuvastatin 20–40 mg), moderate-intensity (MI-S, 10–20 5–10 simvastatin mg) low-intensity (LI-S, 10 groups. With baseline follow-up LDL-C, percentage reduction was calculated distance investigated within Results Of 7,241 (mean age 61.8±12.4 years 64.2% male), 4,451 (61.5%) had coronary artery disease, 109 (1.5%) peripheral 2,879 (39.8%) cerebrovascular disease. HI-S, MI-S LI-S prescribed 20% (n=1,450), 61.1% (n=4,421) 18.9% (n=1,370) patients, respectively. Mean 2.9±1.0 mmol/L mean value 1.9±0.8 median 46.1%, 40.4%, 32.0% MI-S, LI-S, 42.1%, 31.8%, 14.7% achieved only 23.5%, 18.2%, 8.8% reached both One ten require further reach Conclusion In did not guidelines recommended even statin. Early up-titration addition non-statin may required majority Funding Acknowledgement Type funding sources: None.